| Drug Name: | Methylphenidate (113-45-1) |
|---|---|
| PubChem ID: | 4158 |
| SMILES: | COC(=O)C(C1CCCCN1)C2=CC=CC=C2 |
| InchiKey: | DUGOZIWVEXMGBE-UHFFFAOYSA-N |
| Therapeutic Category: | Central Nervous System Agents, Central Nervous System Stimulants, Dopamine Agents, Dopamine Uptake Inhibitors, Membrane Transport Modulators, Neurotransmitter Agents, Neurotransmitter Uptake Inhibitors |
| Molecular Weight (dalton) | : | 233.311 |
| LogP | : | 2.0853 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 38.33 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Valproic Acid (99-66-1) | Bruxism | Additives | Not understood | Adverse response to methylphenidate in combination with valproic acid |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Dependence | Mu-Type opioid receptor (P35372) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
| Dysuria | Histamine H1 receptor (P35367) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
| Euphoric Mood | Histamine H1 receptor (P35367) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
| Hepatotoxicity | Beta-2 adrenergic receptor (P07550) | Methylphenidate responds to beta(2)-adrenoreceptor stimulation@which leads to methylphenidate hepatotoxicity. [ ADR Type 2 ] | Adrenergic modulation of hepatotoxicity |
| Hyperhidrosis | Histamine H1 receptor (P35367) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
| Restlessness | Histamine H1 receptor (P35367) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category